The Centre for Discovery Brain Sciences (CDBS) carries out research at molecular, cellular, systems and behavioural levels to understand fundamental mechanisms and pathways relevant to brain and body function in health and disease. CDBS investigators exploit rapid advances in the enabling technologies available from genomics, proteomics, imaging, informatics, and in-vivo analysis to understand the function of gene products at the cell, organ and whole-animal level. They exploit the most appropriate model organisms/systems to investigate the delicate balance between high biomedical relevance (for example human, mouse, rat) and high genetic power (such as C. elegans, drosophila or zebrafish). Research focuses on understanding fundamental mechanisms and pathways relevant to human function in health and disease across the life course.