Clinical trials are complex research projects that answer important questions for the health and wellbeing of people across the world. The Nottingham Clinical Trials Unit is a UKCRC-registered CTU with expertise in the core competencies required for the design and conduct of high-quality, high-impact trials. We undertake large, multi-centre clinical trials, nationally and internationally. Ensuring trials are conducted to a high-standard and in an efficient manner is important. We also undertake methodological studies relating to the design and conduct of high-quality, efficient clinical trials, either as stand-alone projects or embedded within clinical trials (for example studies within a trial (SWATs)).