Our aim is to deliver excellent science and clinical research together with people with lived experience of rheumatological conditions. We are delivering novel insights and pragmatic treatment for conditions across the life course and in diverse populations, including osteoarthritis, gout, CPPD disease, immune-mediated inflammatory diseases such as rheumatoid arthritis, and musculoskeletal pain. Our research has informed national and international guidelines on osteoarthritis, gout, CPPD disease, and vaccination. We have combined multi-omics with deep clinical characterisation, linked gut microbiome to musculoskeletal disease, and defined how rheumatological and non-rheumatological conditions interact to define disease and disease management.