We study the genetics, genes and genomes that encompass heredity from bioinformatics and genome-scale modelling to transcriptional regulation and epigenetics. Many HDD members are involved in genomic analyses of eukaryotes (NGS, RNA-Seq, WGS, MeSeq) and regulation of gene expression. Ongoing research projects tackle important questions on the basis of epigenetic regulation (ED, AB, GMc) and gene expression regulation (IAH, AP) in animals. Transcription factors in gene regulation, differentiation, and cancer (IAH, SW) are under investigation. We are applying state-of-the-art CRISPR gene editing and RNA silencing techniques in enhancing our understanding of gene function and expression (IAH, REI, ED, AB, GMc).