The Translation and Clinical Research theme focuses on delivery of an oral/dental translational research pipeline spanning: Systematic reviews to identify clinical knowledge gaps, Early proof of concept, feasibility, pilot studies, Phase 3 efficacy and effectiveness trials, often incorporating mechanistic evaluation to advance understanding of how the interventions work, Electronic health record data analytics. Our clinical research is focused to improve oral health and bring new innovations into NHS care. We support a broad portfolio spanning caries and dental erosion, dental trauma, paediatrics, pain management, prosthodontics, and links between periodontology and systemic health. We have established a strong bi-directional knowledge-transfer collaborations between medicine and dental research. These collaborations have extended our portfolio to include: Major diseases with known or emerging links to oral disease notably, cardiovascular research (VINDICATE MRC), rheumatoid arthritis (CADERA, NIHR-EME £1.13m) and multiple sclerosis (MS-SMART NIHR-EME £2.9m MS-STAT2 NIHR-HTA £3.84M MS-OCTOPUS MSS £12.99M CHARIOT-MS NIHR-EME £2.04M) Antimicrobial stewardship to limit antimicrobial resistance (ALABAMA NIHR-PGfAR £2.5m and APTiTUDE NIHR-DRF) Pain management (Trigeminal neuralgia associated with MS).