Our research focuses on skeletal muscle structure and function using a range of approaches from assessment of fundamental molecular mechanisms that underlie excitation-contraction coupling through to whole-body functional measures that underpin muscle performance. Our interests lie in the muscle itself, including blood vessels and fibre composition, as well as in the neural mechanisms and pathways through which the central nervous system and skeletal muscles communicate.We investigate the processes of muscle fatigue and atrophy/hypertrophy, and examine how these can be influenced by a range of interventions including physical activity, stimulation, hypoxia, nutrition, exercise training and drugs. We also explore the mechanisms and potential therapies for skeletal muscle pathology seen in muscle ischaemia, atrophy or hypertrophy, heart failure, malignant hyperthermia, and accompanying statin treatment.