Undertake research that offers the opportunity to understand fundamental mechanisms leading to life with our Cellular and Molecular Physiology research degree. You’ll explore molecular and/or computational approaches to studying homeostatic mechanisms and examine how their disruption leads to disease processes that can be targeted with the aim of improving patient outcomes.IntroductionThe Institute of Systems, Molecular and Integrative Biology (ISMIB) was established to integrate cutting-edge and clinical research across the Faculty of Health and Life Sciences. Programmes of work across ISMIB are varied and are led by world experts in their fields.Cellular and molecular physiology focuses on understanding how molecular and cellular processes give rise to complex physiologic functions. We have expertise in all aspects of modern physiology, ranging from the regulation of gene expression to cell, tissue, organoid and whole organism biology.The University has a long and prestigious history in this research area and is a leading international centre for research into the fundamental principles of human physiology. We’re developing collaborative ways to address important physiological questions, providing vital translational links to clinicians at the bedside.Research topicsResearch in this area includes the study of molecular structure and function and molecular interactions and cell signalling. Another key focus is complex cellular phenotypes and communications that underlie the integrated functions of the tissues and organ systems comprising higher living organisms.Research extends from molecular, biophysical and computational methods to developmental and post-genomic physiologic strategies, with model organisms ranging from bacteria and yeast to fruit-flies, worms, mouse and man.We particularly welcome research proposals around the following themes:Intestinal epithelial cell biology in health and diseaseNeuronal signalling, integrating expertise in cell biology, structural biology and the use of model organisms to investigate aging, neurodegeneration and addictionCalcium signalling in health and disease, particularly focused on the role of Ca2+ signalling, mitochondrial function and bioenergetics in pancreatitis and regulated secretionVascular biology, including the therapeutic use of vascular stents