The human body works through complex interactions between ions, atoms, molecules, cells and systems. Whilst allowing maintenance of diverse functions in health, even subtle changes can result in disease. Understanding how these components operate in normal physiology and how they malfunction in disease provides the opportunity to understand how we target disease and how new therapies might be developed. Physiology is the study of study of the mechanisms and functions within living systems from the ionic level up to the whole animal. To maintain healthy function, all of these aspects must operate optimally, including adapting to changes in the internal or external environment. This course will develop your understanding from the ionic level through to the integration of whole systems that are required to sustain life. This will provide a foundation for understanding how often subtle changes can underlie disease, how we are able to treat disease and how future generations of scientists may develop improved and new treatments.